Revealing the Mechanisms of Sex Differences in Aging.
The Integration Initiative: Sex, Aging, Genomics, and Evolution (IISAGE) is an NSF-funded Biological Integration Institute aimed at understanding the functional genomic basis of differences in lifespan and aging between sexes across a wide range of animals. We are comprised of 11 research laboratories spread across 9 institutions.
Why do we study sex-specific aging?
There is immense variation in how females and males age in the animal kingdom. In humans, sex differences in aging are strong, with females living longer. In model organisms, we can study how sex differences are impacted by genetics and the environment, and how these factors influence distinct aging processes in females and males. By studying diverse species, we can better understand conserved mechanisms regulating sex-specific aging across the animal kingdom.
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Special thanks to the National Science Foundation for providing the funding that enables our research.
