Below is a list of publications that have been supported through funding by IISAGE.

Sex differences in DNA methylation in bats

Jack G. Rayner, Samantha L. Bock, Andrew J. Lonski, Nicole C. Riddle, Gerald S. Wilkinson bioRxiv 2025.05.13.653776; 

doi: https://doi.org/10.1101/2025.05.13.653776

Sex Differences in Telomere Length in a Bat With Female-Biased Longevity

Rayner, J.G., Marshall, A., Adams, D.M., Kaiser, J., Armenta, K. and Wilkinson, G.S. (2025), Sex Differences in Telomere Length in a Bat With Female-Biased Longevity. Ecol Evol, 15: e71378. 

doi: https://doi.org/10.1002/ece3.71378

DNA Methylation Dynamics Reflect Sex and Status Differences in Mortality Rates in a Polygynous Bat

Adams, D.M., Rayner, J.G., Hex, S.B.S.W. and Wilkinson, G.S. (2025), DNA Methylation Dynamics Reflect Sex and Status Differences in Mortality Rates in a Polygynous Bat. Mol Ecol, 34: e17745. 

doi: https://doi.org/10.1111/mec.17745

Comparative Transcriptomic Analysis of Embryonic Stem Cells (ESCs) across Mammalian Species

Yifei Fang, Yue Su, Richard Meisel, James R Walters, Tony Gamble, Eric C. Randolph, Xingtan Yu, Meihong Shi, Guangsheng Li, Jingzhi Zhang, IISAGE Consortium, Xiuchun (Cindy) Tian, Yong Tang, Jingyue (Ellie) Duan bioRxiv 2025.03.11.642582; 

doi: https://doi.org/10.1101/2025.03.11.642582

Sex-biased Transcriptome in in vitro Produced Bovine Early Embryos

Meihong Shi, Guangsheng Li, Hannah Marie Araujo, Angie S Lee, Jingzhi Zhang, Yoke Lee Lee, IISAGE Consortium, Soon Hon Cheong, Jingyue (Ellie) Duan

bioRxiv 2025.03.04.641446; 

doi: https://doi.org/10.1101/2025.03.04.641446

TimeFlies: an snRNA-seq aging clock for the fruit fly head sheds light on sex-biased aging

Nikolai Tennant, Ananya Pavuluri, Kate O’Connor -Giles, Gunjan Singh, Erica Larschan, Ritambhara Singh bioRxiv 2024.11.25.625273; 

doi: https://doi.org/10.1101/2024.11.25.625273

Sex-biased gene content is associated with sex chromosome turnover in Danaini butterflies

Pablo Mora, Monika Hospodářská, Anna Chung Voleníková, Petr Koutecký, Jana Štundlová, Martina Dalíková, James R. Walters, Petr Nguyen. Sex-biased gene content is associated with sex chromosome turnover in Danaini butterflies. Mol Ecol (2024). doi: https://doi.org/10.1111/mec.17256

Comparative transcriptomic analysis of bovine mesenchymal stromal cells reveals tissue-source and species-specific differences

Nikola Danev, Guangsheng Li, Jingyue Ellie Duan, Gerlinde R Van de Walle. Comparative transcriptomic analysis of bovine mesenchymal stromal cells reveals tissue-source and species-specific differences. iScience. (2024).

doi: https://doi.org/10.1016/j.isci.2024.108886

Resistance to age-related hearing loss in the echolocating big brown bat (Eptesicus fuscus)

Grace Capshaw, Clarice A. Diebold, Danielle M. Adams, Jack G. Rayner, Gerald S. Wilkinson, Cynthia F. Moss and Amanda M. Lauer. Resistance to age-related hearing loss in the echolocating big brown bat (Eptesicus fuscus). Proc Biol Sci. (2024).

doi: https://doi.org/10.1098/rspb.2024.1560

Hallmarks of aging: A user’s guide for comparative biologists

Peggy R Biga, Jingyue E Duan, Tristan E Young, Jamie R Marks, Anne Bronikowski, Louis P Decena, Eric C Randolph, Ananya G Pavuluri, Guangsheng Li, Yifei Fang, Gerald S Wilkinson, Gunjan Singh, Nathan T Nigrin, Erica N Larschan, Andrew J Lonski, Nicole C Riddle, IISAGE Consortium. Hallmarks of aging: A user’s guide for comparative biologists. Ageing Research Reviews. (2024).

doi: https://doi.org/10.1016/j.arr.2024.102616

2023

Comparative analysis of animal lifespan

Nicole C. Riddle, Peggy R. Biga, Anne M. Bronikowski, James R. Walters, Gerald S. Wilkinson & IISAGE Consortium. Comparative analysis of animal lifespanGeroScience (2023).

doi: https://doi.org/10.1007/s11357-023-00984-2

CellBiAge: Improved single-cell age classification using data binarization

Doudou Yu, Manlin Li, Guanjie Linghu, Yihuan Hu, Kaitlyn H. Hajdarovic, An Wang, Ritambhara Singh, Ashley E. Webb. CellBiAge: Improved single-cell age classification using data binarization. Cell Rep (2023).

doi: https://doi.org/10.1016/j.celrep.2023.113500

2022

Sex-specific aging in animals: Perspective and future directions

Anne M. Bronikowski, Richard P. Meisel, Peggy R. Biga, James R. Walters, Judith E. Mank, Erica Larschan, Gerald S. Wilkinson, Nicole Valenzuela, Ashley Mae Conard, João Pedro de Magalhães, Jingyue (Ellie) Duan, Amy E. Elias, Tony Gamble, Rita M. Graze, Kristin E. Gribble, Jill A. Kreiling, Nicole C. Riddle. Sex-specific aging in animals: Perspective and future directions. Aging Cell (2022).

doi: https://doi.org/10.1111/acel.13542