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Revealing the Mechanisms of Sex Differences in Aging.

The Integration Initiative: Sex, Aging, Genomics, and Evolution (IISAGE) is an NSF-funded Biological Integration Institute aimed at understanding the functional genomic basis of differences in lifespan and aging between sexes across a wide range of animals. We are comprised of 11 research laboratories spread across 9 institutions.

ABOUT OUR INSTITUTE

Why do we study sex-specific aging?

There is immense variation in how females and males age in the animal kingdom. In humans, sex differences in aging are strong, with females living longer. In model organisms, we can study how sex differences are impacted by genetics and the environment, and how these factors influence distinct aging processes in females and males. By studying diverse species, we can better understand conserved mechanisms regulating sex-specific aging across the animal kingdom.

Learn more

Upcoming Seminar

Monday, May 5th, 2025 | 10:00 AM – 11:00 AM (CST)

Stay Updated!

IISAGE makes a presence at the 66th Annual Drosophila Research Conference! Our team of fly scientists showcased their work to the public, engaging the science community with recent discoveries regarding aging in the Drosophila species! šŸŖ° #Dros25

— Integration Initiative: Sex, Aging, Genomics, and Evolution (@iisage.bsky.social) 2025-03-25T15:24:10.388Z

Check out Dr. Wilkinson's team in action, doing fieldwork on big brown bats in Trinidad! šŸ¦‡šŸŒæ #BatResearch #Fieldwork #AgingResearch #IISAGE

— Integration Initiative: Sex, Aging, Genomics, and Evolution (@iisage.bsky.social) 2025-01-21T15:20:24.122Z

Special thanks to the National Science Foundation for providing the funding that enables our research.