There is immense variation in how females and males age in the animal kingdom. In humans, sex differences in aging are strong, with females living longer. In model animals, we can see how sex differences are impacted by environment and genetics. The Integration Initiative: Sex, Aging, Genomics, and Evolution (IISAGE) focuses on how genome architecture, organismal biology, and phenotypic plasticity underpin sex-specific aging, and how it evolves. LEARN MORE

IISAGE is an NSF-funded Biological Integration Institute aimed at understanding the functional genomic basis of differences in lifespan and aging between sexes across a wide range of animals. We are comprised of 11 research laboratories spread across 8 institutions.